Endocrine Abstracts

Objectives: Assess the dose of levothyroxine in relation to TSH and FT4 at diagnosis of AHT in children with SH and OH.Methods: Two hundred one children (155 girls) with AHT were devided according to TSH and FT4 levels at diagnosis of hypothyroidism [SH-FT4 >1.0 ng/dl: Group 1: TSH: 5–7.5 mU/l, Group 2: TSH: >7.5 mU/l, OH: Group 3: TSH>7.5 mU/l and FT4 ≤1.0 ng/dl]. Mean L-T4 dose was reported in μg/Kg per day at diagnosis and ...

Aim: To evaluate whether anthropometric indices and acanthosis nigricans can be useful markers for early detection of Insulin Resistance and Metabolic Syndrome (MetS) in overweight and obese children.Methods: Data from 510 prepubertal children (40% boys), 12.9% overweight and 87.1% obese with mean age 9.7±2.5 years were analyzed. Logistic regression analysis was used to investigate which factors were associated with HOMA-IR >3 and metabolic synd...

In true precocious puberty, the increased gonadal steroid secretion increases height velocity, somatic and psychosocial development, and the rate of skeletal maturation and can lead to short adult height. The aim is to assess the impact of suppression therapy of CPP with triptorelin on final adult height and the timing of menarche and pattern of menstrual cycle post-treatment.Materials and methods: Nineteen girls, with CPP, which had completed at least t...

Objectives: GH in addition to promote linear growth during childhood influences several key metabolic processes as well. In the transition period, from late adolescence to early adulthood, GH plays an important role in skeletal mineralization and muscle mass maturation as well as in developing a favorable cardiometabolic profile. Therefore, several lines of evidence propose GH replacement to be continued if GH evaluation at the transition age fulfills established criteria. The...